Applications of quantum science to computing, cryptography, and imaging are on their way to becoming key next- generation technologies. Owing to the high-speed transmission and exceptional noise properties of photons, quantum photonic architectures are likely to play a central role. A long-standing hurdle, however, has been the realization of robust, device-compatible single-photon sources that can be activated and controlled on demand. Here we demon- strate large arrays of room-temperature quantum emitters in two-dimensional hexagonal boron nitride (hBN). The large energy gap inherent to this van der Waals material stabilizes the emitters at room temperature within nanoscale regions defined by substrate-induced deformation of few-atomic-layer hBN. Through the control of pillar geometry, we demonstrate an average of ∼2 emitters per site for the smallest pillars (75 nm diameter). These findings set the stage for realizing arrays of room-temperature single-photon sources through the combined control of strain and external electrostatic potentials.